kinoprene





Place syntheses below: per. joseph williams, charles igwe. dionne milan. Joseph, Charles, and Dionne: This is a good literature synthesis. I have a hard time making out the written portion, but it looks like the main part of this synthesis is a claisen condensation. The only thing that I would suggest is to provid a reference to the journal paper or book where you found this. Possibly type up the written part so we can read it, and definately provide a reterosynthetic analysis. THANKS DR B..BELOW IS THE WRITTEN PORTION TYPED UP FOR BETTER CLARITY. .JCD.

THE STARTING MATERIAL IS 3,7 DI-METHYL OCTALDEHYDE,. IT UNDERGOES CLISEN CONDENSATION REACTION WITH DI-METHYL GLUTANOTE IN 50%, 3% METHANOL SOLUTION AND AT LOW TEMPERATURE THE DERIVATIVE PRODUCED UNDERGOES ALKALINE HYDROLYSIS WITH 2 EQV NaOH FOLLOWED BY THE DECARBOXYLATION IN DIMETHYL PYRIDINE IN TOLUENE AT 100* Dge C. AND FURTHER B NaOMe/methanol at 70 Dge C.THE Z ALKALINE CARBOXYLIC ACID PRODUCED UNDERGOES ISOMERIZATION TO TRANS BY 1% BENZENE THIOL (1%) IN A FLUIDIZES BED TO PRODUCE THE TRANS ISOMER. TEH CARBOXYLIC ACID IS THEN CONVERTED TO CORRESPONDING ACID CHLORIDE BY TREATMENT WITH So2CI2 IN DMF AT TEMP <35 Dge C. THE ACID CHLORIDE REACTS WITH HO-CH2-=CH TO PRODUCE KINOPRINE .
 * Dr B,**
 * THIS IS THE WRITTEN PART AND THE RETROCYNTHESIS IS SHAWN IN THE TWO SKETCH ABOVE WITH THE STARTING MATERIAL SHOWN IN THE SECOND SKETCH.**
 * (1) REFERENCE. A GUIDE BOOK TO ORGANIC SYMTHESIS. IAN FLEMING.**
 * (2) WADE, ORGO BOOK .**
 * JOSEPH, CHARLES ,DIONNE**.